Fig. 3
From: The role of MORC3 in silencing transposable elements in mouse embryonic stem cells
MORC3 localizes at transcription start sites and at ERVs. a Distribution of 9120 MORC3 peaks over genomic features in WT V6.5 mESCs (n = 4 replicates). b Distribution of MORC3 peaks localized in intergenic regions. c MORC3 enrichment at H3K9me3 marked regions. d MORC3 enrichment at promoters of all mouse genes. e Representative genome browser track at the Ostm1 and Map3k7 loci showing MORC3 peaks at promoters as well as at upstream ERVs. f MORC3 ChIP-qPCR at the Ostm1 promoter and its nearby ERV (LTRIS2) and at the Map3k7 promoter and its nearby ERV (IAPEz-int). g Metaplot showing H3K9me3 coverage (rpkm) at ERV1, ERVK, ERVL, IAPEzint and 20 kb flanking regions