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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Single-nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell-type-specific gene regulatory variation

Fig. 6

TCF/LEF family as a mediator for trans-acting variation in neurons. A Motif enrichment analysis for regions of differential accessibility between C57BL/6J and A/J in neurons. B, C Regions of differential accessibility with motif for TCF/LEF family show increased accessibility in neurons compared to other cell types. DE Lef1 is highly expressed in endothelial stalk, Tcf7l1 shows low expression in all cell types, while Tcf7l2 is abundant in neurons and polydendrocytes. See also Additional file 1: Figure S3

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