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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Single-nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell-type-specific gene regulatory variation

Fig. 3

Identification of cell-type-specific TFs controlling cellular identity. A Heatmap showing the enriched signal of cell-type-identity peaks in eight cell types. The analysis was done on C57BL/6J midbrain snATAC-seq. The background is constructed by merging the sampling reads (366,278 reads/cell type) from each cell type. The raw signal is normalized to the background and library, following log2-transformation. The normalized signal is plotted 3 kb up- and downstream of peaks. B Motif enrichment analysis on cell-type-identity peaks. The PWM logos, names of the associated TFs and p values are shown for each motif. The motifs are ranked according to p values

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Epigenetics & Chromatin

ISSN: 1756-8935