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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: Single-nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell-type-specific gene regulatory variation

Fig. 1

Midbrain snATAC-seq identifies cell-type-specific accessibility. A Clustering of snATAC-seq from C57BL/6J and A/J with corresponding cell-type proportions. Major cell types can be identified based on snATAC-seq profiles, with neurons having the biggest proportion on both strains. Cell types in C57BL/6J and A/J have comparable proportions with more than half of nuclei being identified as neurons. B Cell-type-specific accessibility is observed in marker genes. The genomic tracks are from C57BL/6J midbrain snATAC-seq. The expression profiles measured as transcript per 100,000 in cluster. Rpl13a is used as a house keeping gene to normalize the snATAC-seq signal. See also Additional file 1: Figures S1 and S2

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