Fig. 1

Illustration of genome architecture and the corresponding Hi-C interaction maps. Top panel: interaction heatmaps A, B, C, D are in different scales (kb or Mb per pixel) to correlate with the diagrams of 3D structures in the bottom panel, yellow boxes in A and B are identified TADs and small blue boxes in A indicate chromatin loops. The purple box in A is a frequently interacting region, with its classical “V” shape pattern coloured in purple dotted lines. Heatmaps were generated using Juicebox [29] with published Hi-C data of GM12878 [3]. Bottom panel: diagrams of 3D structures in the genome