Fig. 2

Overview of MAGAR and methQTL results. A MAGAR is an R-package utilizing a two-stage protocol. After data import via established software packages, CpGs are clustered into CpG-correlation blocks in a four-step procedure. In the second stage, methQTLs are called for each correlation block separately. B Number of methQTLs identified by MAGAR for T cells, B cells, ileum, and rectum samples. Overlap between the methQTLs identified per tissue/cell type with methQTLs identified in the validation cohort (C) and in published methQTLs from blood [12] and fetal brain samples [38] (D). The methQTLs were reduced to those methQTLs affecting CpGs present on the 450k microarray