Fig. 1

Cell type-specific DNA methylation patterns in the discovery data set. A Heatmap (blue low, red high DNA methylation levels) of the 1000 most variably methylated genome-wide bins of size 5 kb. Hierarchical clustering of samples and bins was performed using Euclidean distance and complete linkage. B PCA plot of genome-wide DNA methylation data at the single-CpG level. The first two principal components are displayed. C Boxplots depicting the distributions of LUMP estimates for the overall immune cell content of the different cell types/tissues. The P-value was computed using a two-sided t-test