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Table 2 Genes that were differentially expressed between ventricles from juvenile snapping turtles exposed to normoxia (N21) or hypoxia (H10) during embryonic development

From: Developmental programming of DNA methylation and gene expression patterns is associated with extreme cardiovascular tolerance to anoxia in the common snapping turtle

Locus # Gene name Gene symbol Log2 (H10/N21)
CS000018264 Zinc finger family member 783   − 2.834627001
CS000001503    − 2.701680389
CS000000288 Myosin heavy chain 7   − 2.041584511
CS000024278 RALY RNA-binding protein-like RALYL − 1.527633917
CS000008734 Mast cell proteinase-3   − 1.496662823
CS000015120    − 1.356777695
CS000017586 Zinc finger protein 3   − 1.273941158
CS000023536 C-type lectin-domain family 2, member e   − 1.208247243
CS000009112 Calcium-binding protein 5 CABP5 − 1.181213024
CS000003610 Serine/threonine kinase 32A STK32A − 1.121027915
CS000017023 Adhesion G protein-coupled receptor B2   − 1.110900385
CS000011584 Tripartite motif containing 58   − 1.045883825
CS000002712 Pseudouridylate synthase 1 PUS1 − 1.035714387
CS000021405    − 1.006176746
CS000020555 Granzyme H GZMH − 0.853897751
CS000010063 General transcription factor IIA subunit 1-like GTF2A1L − 0.792335632
CS000018042 Tribbles pseudokinase 1 TRIB1 − 0.765772922
CS000008605 Contactin associated protein 1 CNTNAP1 − 0.743987654
CS000022576 Immunoglobulin heavy constant gamma 2 (G2m marker) − 0.740245463
CS000002010 Nuclear receptor subfamily 1 group D member 2-like − 0.731931571
CS000016349 Zinc finger protein 3   − 0.722476444
CS000011191 Deoxyribonuclease 1-like 3 DNASE1L3 − 0.710756946
CS000002882 Short chain dehydrogenase (predicted)   − 0.697002063
CS000004234 Lysozyme C-like   − 0.694683419
CS000019361 Sperm flagellar 2   − 0.637371303
CS000009788 Bone morphogenetic protein 10 BMP10 − 0.625646157
CS000022673 Centrosomal protein 295   − 0.621246238
CS000010768 MAM domain containing 4 MAMDC4 − 0.616068017
CS000002550 Family with sequence similarity 217 member B FAM217B − 0.606523849
CS000021864 PZP, alpha-2-macroglobulin-like   − 0.600912295
CS000022474 Dedicator of cytokinesis 2   − 0.593278276
CS000007572    − 0.564178825
CS000002388 Suppression of tumorigenicity 14 ST14 − 0.563702692
CS000010941 Coiled-coil domain containing 40 CCDC40 − 0.526253468
CS000018526 Modulator of smoothened protein MOSMO − 0.507345817
CS000008639 Kell blood group, metallo-endopeptidase KEL − 0.501729677
CS000008272    − 0.500144159
CS000013388 Coiled-coil domain containing 69   − 0.488161437
CS000023033 Calcitonin receptor CALCR − 0.478006366
CS000013081 PR/SET domain 8 PRDM8 − 0.470914245
CS000010506 NAD(P)H quinone dehydrogenase 2 NQO2 − 0.470257899
CS000010015 Proteolipid protein 1 PLP1 − 0.451285412
CS000009837 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 PFKFB1 − 0.445995285
CS000013172 Sperm flagellar 2 SPEF2 − 0.405206127
CS000007175 Adhesion G protein-coupled receptor L3 ADGRL3 − 0.390432656
CS000018864 Zinc finger protein 3   − 0.387733152
CS000003471 DNA damage inducible transcript 4-like DDIT4L − 0.381244306
CS000013715 THAP domain containing 9 THAP9 − 0.367754654
CS000016980 Leucine rich repeat containing 8 family member D LRRC8D − 0.360578313
CS000024331 Ceramide synthase 4 CERS4 − 0.329175611
CS000004429 Diphthamide biosynthesis 7 DPH7 − 0.31321296
CS000024488 Endogenous retrovirus group MER34 member 1   − 0.283738212
CS000002360 Activating transcription factor 1 ATF1 − 0.279120084
CS000015148 Tumor necrosis factor superfamily member 10 TNFSF10 − 0.25585253
CS000001723 ATM serine/threonine kinase ATM − 0.249457117
CS000014235 Anthrax toxin receptor 2 ANTXR2 − 0.244822743
CS000023516 Hypoxia inducible factor 1 alpha subunit HIF1A − 0.237980337
CS000010455 SURF1, cytochrome c oxidase assembly factor SURF1 − 0.222451553
CS000021833 Rho GTPase activating protein 45 ARHGAP45 − 0.221222304
CS000013956 Tribbles pseudokinase 2 TRIB2 − 0.217959675
CS000002385 Rho GTPase-activating protein 32 ARHGAP32 − 0.215929188
CS000004163 Solute carrier family 4 member 2 SLC4A2 − 0.212349304
CS000010124 Solute carrier family 35 member A1 slc35a1 − 0.20854517
CS000007017 Cingulin-like 1 CGNL1 − 0.198504808
CS000009705 F-box and leucine rich repeat protein 20 FBXL20 − 0.168085068
CS000025011 Retinoic acid receptor, alpha   0.154424605
CS000009251 Taxilin beta TXLNB 0.158953455
CS000005867 Epidermal growth factor receptor pathway substrate 8 EPS8 0.163637442
CS000023373 Mannosidase beta MANBA 0.166087668
CS000021122 Sprouty related EVH1 domain containing 2 SPRED2 0.170050721
CS000008545 Erb-b2 receptor tyrosine kinase 2 ERBB2 0.187176414
CS000000599 Tubulin folding cofactor B TBCB 0.195969098
CS000013318 G protein subunit gamma 10 GNG10 0.208058965
CS000003073 Cadherin 11, type 2, OB-cadherin (osteoblast)   0.208906093
CS000008574 2′,3′-Cyclic nucleotide 3′ phosphodiesterase CNP 0.212460195
CS000007985 STARD3 N-terminal-like STARD3NL 0.219747393
CS000009739 Tropomyosin 3 TPM3 0.236963141
CS000024894 Serine/threonine kinase 38-like STK38L 0.238422059
CS000015359 Spectrin beta, erythrocytic   0.241602606
CS000013674 Eva-1 homolog C EVA1C 0.245944042
CS000010784 Cholesteryl ester transfer protein CETP 0.246380083
CS000010497 Serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.248181093
CS000009948    0.252507277
CS000008411 Integrin subunit alpha 11 ITGA11 0.254329861
CS000003646 Ubiquitin conjugating enzyme E2 B UBE2B 0.254817922
CS000014028 C-type lectin-domain family 2 member D   0.264505749
CS000011229 Ribonuclease H2 subunit C rnaseh2c 0.27146634
CS000023524 Protein tyrosine phosphatase, non-receptor type 23   0.277562695
CS000009501 Heparan sulfate 6-O-sulfotransferase 2 HS6ST2 0.28065352
CS000005400 Inositol-trisphosphate 3-kinase A ITPKA 0.29921558
CS000008774 Mitogen-activated protein kinase kinase kinase 5 MAP3K5 0.309585444
CS000019402 Heat shock protein family B (small) member 3 HSPB3 0.328843966
CS000014776 Bardet-Biedl syndrome 1 protein   0.33633198
CS000004507 Cathepsin L ctsl 0.344555132
CS000013316 KIAA0368 KIAA0368 0.353983994
CS000020738 Protein phosphatase, Mg2+/Mn2+-dependent 1H PPM1H 0.35982697
CS000010357 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.370923213
CS000000947 Pleckstrin homology-like domain family A member 3 PHLDA3 0.371384191
CS000000189 Protein kinase AMP-activated non-catalytic subunit beta 2 PRKAB2 0.376457859
CS000021606 Ependymin related 1 EPDR1 0.384457752
CS000013259 Centromere protein H CENPH 0.384685483
CS000004917 Bone morphogenetic protein receptor type 2 BMPR2 0.400771813
CS000008544 Growth factor receptor bound protein 7 GRB7 0.443902422
CS000001051 Monooxygenase DBH-like 1 MOXD1 0.459634006
CS000003463 Alcohol dehydrogenase 4 (class II), pi polypeptide ADH4 0.494122016
CS000017173 Solute carrier family 2 member 11 SLC2A11 0.501060861
CS000011090 Secreted phosphoprotein 1 SPP1 0.517276571
CS000021119 Endogenous retrovirus group MER34 member 1   0.524982887
CS000014447 PDZ-binding kinase PBK 0.542088418
CS000011287 Dual specificity protein phosphatase 10-like   0.543863344
CS000009633 Activated leukocyte cell adhesion molecule ALCAM 0.548683718
CS000010233 EFR3 homolog B   0.554021781
CS000001795 Transmembrane protein 71 TMEM71 0.60589964
CS000001243 Myelin basic protein MBP 0.606334331
CS000012858 Suppressor of cytokine signaling 2 SOCS2 0.635342108
CS000001161 Transmembrane protein 200C tmem200c 0.646446549
CS000020994 Transmembrane protein 151B-like   0.64955796
CS000004537 Charged multivesicular body protein 4C CHMP4C 0.649900032
CS000008619 ETS variant 4 ETV4 0.668839089
CS000014855 Killer cell lectin-like receptor subfamily G, member 2 0.669227747
CS000018990 Collagen type XXII alpha 1 chain COL22A1 0.675489915
CS000019220 Keratin 8 KRT8 0.683602204
CS000019009 Thrombospondin type 1 domain containing 7A THSD7A 0.718432909
CS000005131 Glutaredoxin GLRX 0.740909237
CS000019856 TNF receptor associated factor 2   0.756354667
CS000004598    0.765230508
CS000006964 Adaptor related protein complex 1 sigma 3 subunit AP1S3 0.765814686
CS000021260 Potassium voltage-gated channel subfamily A member 4 KCNA4 0.854709853
CS000003440 Apolipoprotein C1 apoc1 0.878140809
CS000019191 Interaction protein for cytohesin exchange factors 1 IPCEF1 0.879401672
CS000009567 Keratin 18 KRT18 0.925644492
CS000022727 Fer-1-like family member 4 FER1L4 0.964212443
CS000020607 DNA polymerase nu POLN 1.00608115
CS000018642 Hyaluronan-binding protein 2 HABP2 1.034969644
CS000014808 Synaptonemal complex protein 1 SYCP1 1.124476724
CS000004949 Myosin light chain 1 MYL1 1.168968857
CS000011884 Ubiquinol-cytochrome c reductase complex assembly factor 2 1.298675033
CS000004501    1.320990056
CS000004709 Heparan sulfate–glucosamine 3-sulfotransferase 2 HS3ST2 1.353228055
CS000009646 Adhesion G protein-coupled receptor G7 ADGRG7 1.423863767
CS000001877 Glycoprotein nmb GPNMB 1.608451449
CS000012011 Coagulation factor III, tissue factor F3 1.645631227
CS000004554 Complement C1r C1R 1.873883015
CS000000330 Matrix metallopeptidase 25 MMP25 1.977548442
CS000012602 Neuritin 1 NRN1 2.508897571
CS000019631 Perforin 1   2.667492969
CS000021046 Complement C1r subcomponent   2.710546811
CS000013720 Vesicle-associated membrane protein 8-like   3.126479237
CS000010724 LIM homeobox 5 LHX5 3.176148053
CS000018878    4.264821788
CS000012122 Astacin-like metalloendopeptidase   4.556056058
  1. The difference in expression in the last column is calculated as the log2 of the ratio of gene expression in turtles exposed to hypoxia divided by gene expression in turtles exposed to normoxia during embryonic development. Negative values indicate the gene was downregulated in the hypoxic group, while positive values indicate the gene was upregulated in the hypoxic group. The transcriptome was analyzed via RNA-Seq. Differences in gene expression were considered significant when results from DESeq2 and ANOVA were concordant