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Table 2 Genes that were differentially expressed between ventricles from juvenile snapping turtles exposed to normoxia (N21) or hypoxia (H10) during embryonic development

From: Developmental programming of DNA methylation and gene expression patterns is associated with extreme cardiovascular tolerance to anoxia in the common snapping turtle

Locus #

Gene name

Gene symbol

Log2 (H10/N21)

CS000018264

Zinc finger family member 783

 

− 2.834627001

CS000001503

  

− 2.701680389

CS000000288

Myosin heavy chain 7

 

− 2.041584511

CS000024278

RALY RNA-binding protein-like

RALYL

− 1.527633917

CS000008734

Mast cell proteinase-3

 

− 1.496662823

CS000015120

  

− 1.356777695

CS000017586

Zinc finger protein 3

 

− 1.273941158

CS000023536

C-type lectin-domain family 2, member e

 

− 1.208247243

CS000009112

Calcium-binding protein 5

CABP5

− 1.181213024

CS000003610

Serine/threonine kinase 32A

STK32A

− 1.121027915

CS000017023

Adhesion G protein-coupled receptor B2

 

− 1.110900385

CS000011584

Tripartite motif containing 58

 

− 1.045883825

CS000002712

Pseudouridylate synthase 1

PUS1

− 1.035714387

CS000021405

  

− 1.006176746

CS000020555

Granzyme H

GZMH

− 0.853897751

CS000010063

General transcription factor IIA subunit 1-like

GTF2A1L

− 0.792335632

CS000018042

Tribbles pseudokinase 1

TRIB1

− 0.765772922

CS000008605

Contactin associated protein 1

CNTNAP1

− 0.743987654

CS000022576

Immunoglobulin heavy constant gamma 2 (G2m marker)

− 0.740245463

CS000002010

Nuclear receptor subfamily 1 group D member 2-like

− 0.731931571

CS000016349

Zinc finger protein 3

 

− 0.722476444

CS000011191

Deoxyribonuclease 1-like 3

DNASE1L3

− 0.710756946

CS000002882

Short chain dehydrogenase (predicted)

 

− 0.697002063

CS000004234

Lysozyme C-like

 

− 0.694683419

CS000019361

Sperm flagellar 2

 

− 0.637371303

CS000009788

Bone morphogenetic protein 10

BMP10

− 0.625646157

CS000022673

Centrosomal protein 295

 

− 0.621246238

CS000010768

MAM domain containing 4

MAMDC4

− 0.616068017

CS000002550

Family with sequence similarity 217 member B

FAM217B

− 0.606523849

CS000021864

PZP, alpha-2-macroglobulin-like

 

− 0.600912295

CS000022474

Dedicator of cytokinesis 2

 

− 0.593278276

CS000007572

  

− 0.564178825

CS000002388

Suppression of tumorigenicity 14

ST14

− 0.563702692

CS000010941

Coiled-coil domain containing 40

CCDC40

− 0.526253468

CS000018526

Modulator of smoothened protein

MOSMO

− 0.507345817

CS000008639

Kell blood group, metallo-endopeptidase

KEL

− 0.501729677

CS000008272

  

− 0.500144159

CS000013388

Coiled-coil domain containing 69

 

− 0.488161437

CS000023033

Calcitonin receptor

CALCR

− 0.478006366

CS000013081

PR/SET domain 8

PRDM8

− 0.470914245

CS000010506

NAD(P)H quinone dehydrogenase 2

NQO2

− 0.470257899

CS000010015

Proteolipid protein 1

PLP1

− 0.451285412

CS000009837

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

PFKFB1

− 0.445995285

CS000013172

Sperm flagellar 2

SPEF2

− 0.405206127

CS000007175

Adhesion G protein-coupled receptor L3

ADGRL3

− 0.390432656

CS000018864

Zinc finger protein 3

 

− 0.387733152

CS000003471

DNA damage inducible transcript 4-like

DDIT4L

− 0.381244306

CS000013715

THAP domain containing 9

THAP9

− 0.367754654

CS000016980

Leucine rich repeat containing 8 family member D

LRRC8D

− 0.360578313

CS000024331

Ceramide synthase 4

CERS4

− 0.329175611

CS000004429

Diphthamide biosynthesis 7

DPH7

− 0.31321296

CS000024488

Endogenous retrovirus group MER34 member 1

 

− 0.283738212

CS000002360

Activating transcription factor 1

ATF1

− 0.279120084

CS000015148

Tumor necrosis factor superfamily member 10

TNFSF10

− 0.25585253

CS000001723

ATM serine/threonine kinase

ATM

− 0.249457117

CS000014235

Anthrax toxin receptor 2

ANTXR2

− 0.244822743

CS000023516

Hypoxia inducible factor 1 alpha subunit

HIF1A

− 0.237980337

CS000010455

SURF1, cytochrome c oxidase assembly factor

SURF1

− 0.222451553

CS000021833

Rho GTPase activating protein 45

ARHGAP45

− 0.221222304

CS000013956

Tribbles pseudokinase 2

TRIB2

− 0.217959675

CS000002385

Rho GTPase-activating protein 32

ARHGAP32

− 0.215929188

CS000004163

Solute carrier family 4 member 2

SLC4A2

− 0.212349304

CS000010124

Solute carrier family 35 member A1

slc35a1

− 0.20854517

CS000007017

Cingulin-like 1

CGNL1

− 0.198504808

CS000009705

F-box and leucine rich repeat protein 20

FBXL20

− 0.168085068

CS000025011

Retinoic acid receptor, alpha

 

0.154424605

CS000009251

Taxilin beta

TXLNB

0.158953455

CS000005867

Epidermal growth factor receptor pathway substrate 8

EPS8

0.163637442

CS000023373

Mannosidase beta

MANBA

0.166087668

CS000021122

Sprouty related EVH1 domain containing 2

SPRED2

0.170050721

CS000008545

Erb-b2 receptor tyrosine kinase 2

ERBB2

0.187176414

CS000000599

Tubulin folding cofactor B

TBCB

0.195969098

CS000013318

G protein subunit gamma 10

GNG10

0.208058965

CS000003073

Cadherin 11, type 2, OB-cadherin (osteoblast)

 

0.208906093

CS000008574

2′,3′-Cyclic nucleotide 3′ phosphodiesterase

CNP

0.212460195

CS000007985

STARD3 N-terminal-like

STARD3NL

0.219747393

CS000009739

Tropomyosin 3

TPM3

0.236963141

CS000024894

Serine/threonine kinase 38-like

STK38L

0.238422059

CS000015359

Spectrin beta, erythrocytic

 

0.241602606

CS000013674

Eva-1 homolog C

EVA1C

0.245944042

CS000010784

Cholesteryl ester transfer protein

CETP

0.246380083

CS000010497

Serpin peptidase inhibitor, clade B (ovalbumin), member 6

0.248181093

CS000009948

  

0.252507277

CS000008411

Integrin subunit alpha 11

ITGA11

0.254329861

CS000003646

Ubiquitin conjugating enzyme E2 B

UBE2B

0.254817922

CS000014028

C-type lectin-domain family 2 member D

 

0.264505749

CS000011229

Ribonuclease H2 subunit C

rnaseh2c

0.27146634

CS000023524

Protein tyrosine phosphatase, non-receptor type 23

 

0.277562695

CS000009501

Heparan sulfate 6-O-sulfotransferase 2

HS6ST2

0.28065352

CS000005400

Inositol-trisphosphate 3-kinase A

ITPKA

0.29921558

CS000008774

Mitogen-activated protein kinase kinase kinase 5

MAP3K5

0.309585444

CS000019402

Heat shock protein family B (small) member 3

HSPB3

0.328843966

CS000014776

Bardet-Biedl syndrome 1 protein

 

0.33633198

CS000004507

Cathepsin L

ctsl

0.344555132

CS000013316

KIAA0368

KIAA0368

0.353983994

CS000020738

Protein phosphatase, Mg2+/Mn2+-dependent 1H

PPM1H

0.35982697

CS000010357

Potassium voltage-gated channel subfamily H member 6

KCNH6

0.370923213

CS000000947

Pleckstrin homology-like domain family A member 3

PHLDA3

0.371384191

CS000000189

Protein kinase AMP-activated non-catalytic subunit beta 2

PRKAB2

0.376457859

CS000021606

Ependymin related 1

EPDR1

0.384457752

CS000013259

Centromere protein H

CENPH

0.384685483

CS000004917

Bone morphogenetic protein receptor type 2

BMPR2

0.400771813

CS000008544

Growth factor receptor bound protein 7

GRB7

0.443902422

CS000001051

Monooxygenase DBH-like 1

MOXD1

0.459634006

CS000003463

Alcohol dehydrogenase 4 (class II), pi polypeptide

ADH4

0.494122016

CS000017173

Solute carrier family 2 member 11

SLC2A11

0.501060861

CS000011090

Secreted phosphoprotein 1

SPP1

0.517276571

CS000021119

Endogenous retrovirus group MER34 member 1

 

0.524982887

CS000014447

PDZ-binding kinase

PBK

0.542088418

CS000011287

Dual specificity protein phosphatase 10-like

 

0.543863344

CS000009633

Activated leukocyte cell adhesion molecule

ALCAM

0.548683718

CS000010233

EFR3 homolog B

 

0.554021781

CS000001795

Transmembrane protein 71

TMEM71

0.60589964

CS000001243

Myelin basic protein

MBP

0.606334331

CS000012858

Suppressor of cytokine signaling 2

SOCS2

0.635342108

CS000001161

Transmembrane protein 200C

tmem200c

0.646446549

CS000020994

Transmembrane protein 151B-like

 

0.64955796

CS000004537

Charged multivesicular body protein 4C

CHMP4C

0.649900032

CS000008619

ETS variant 4

ETV4

0.668839089

CS000014855

Killer cell lectin-like receptor subfamily G, member 2

0.669227747

CS000018990

Collagen type XXII alpha 1 chain

COL22A1

0.675489915

CS000019220

Keratin 8

KRT8

0.683602204

CS000019009

Thrombospondin type 1 domain containing 7A

THSD7A

0.718432909

CS000005131

Glutaredoxin

GLRX

0.740909237

CS000019856

TNF receptor associated factor 2

 

0.756354667

CS000004598

  

0.765230508

CS000006964

Adaptor related protein complex 1 sigma 3 subunit

AP1S3

0.765814686

CS000021260

Potassium voltage-gated channel subfamily A member 4

KCNA4

0.854709853

CS000003440

Apolipoprotein C1

apoc1

0.878140809

CS000019191

Interaction protein for cytohesin exchange factors 1

IPCEF1

0.879401672

CS000009567

Keratin 18

KRT18

0.925644492

CS000022727

Fer-1-like family member 4

FER1L4

0.964212443

CS000020607

DNA polymerase nu

POLN

1.00608115

CS000018642

Hyaluronan-binding protein 2

HABP2

1.034969644

CS000014808

Synaptonemal complex protein 1

SYCP1

1.124476724

CS000004949

Myosin light chain 1

MYL1

1.168968857

CS000011884

Ubiquinol-cytochrome c reductase complex assembly factor 2

1.298675033

CS000004501

  

1.320990056

CS000004709

Heparan sulfate–glucosamine 3-sulfotransferase 2

HS3ST2

1.353228055

CS000009646

Adhesion G protein-coupled receptor G7

ADGRG7

1.423863767

CS000001877

Glycoprotein nmb

GPNMB

1.608451449

CS000012011

Coagulation factor III, tissue factor

F3

1.645631227

CS000004554

Complement C1r

C1R

1.873883015

CS000000330

Matrix metallopeptidase 25

MMP25

1.977548442

CS000012602

Neuritin 1

NRN1

2.508897571

CS000019631

Perforin 1

 

2.667492969

CS000021046

Complement C1r subcomponent

 

2.710546811

CS000013720

Vesicle-associated membrane protein 8-like

 

3.126479237

CS000010724

LIM homeobox 5

LHX5

3.176148053

CS000018878

  

4.264821788

CS000012122

Astacin-like metalloendopeptidase

 

4.556056058

  1. The difference in expression in the last column is calculated as the log2 of the ratio of gene expression in turtles exposed to hypoxia divided by gene expression in turtles exposed to normoxia during embryonic development. Negative values indicate the gene was downregulated in the hypoxic group, while positive values indicate the gene was upregulated in the hypoxic group. The transcriptome was analyzed via RNA-Seq. Differences in gene expression were considered significant when results from DESeq2 and ANOVA were concordant