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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Histone deacetylase inhibition leads to regulatory histone mark alterations and impairs meiosis in oocytes

Fig. 3

A critical meiotic step is perturbed in embryonic ovaries exposed to PB. Surface spreads from E15.5 control (A, top row) and PB-treated ovaries (A, bottom row) were immunostained with anti-DMC1 (green) and anti-SYCP3 (red) antibodies (63X magnification). B Surface spreads from E17.5 control (B, top row) and PB-treated ovaries (B, bottom row). C Surface spreads from E18.5 control (C, top row) and PB-treated ovaries (C, bottom row). D Quantitative analysis of the number of DMC1 foci per cell performed on at least twenty E17.5 and E18.5 oocytes from four replicates from different litters; n = 4 for each group; *p < 0.05, nonparametric Mann–Whitney test

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Epigenetics & Chromatin

ISSN: 1756-8935