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Fig. 10 | Epigenetics & Chromatin

Fig. 10

From: Histone deacetylase inhibition leads to regulatory histone mark alterations and impairs meiosis in oocytes

Fig. 10

Decreases in histone H4 acetylation and H3K4me3 levels in adult ovaries following gestational PB exposure. Exposure to PB affects histone H4Ac and H3K4me3 levels in grown oocytes in adult ovaries. A Representative images of control (top) and PB-treated oocytes (bottom) immunostained for MSY2 (oocyte marker, green) or H4Ac (red) (40X magnification). B Quantitative analysis of the H4Ac signals in oocytes and in the surrounding granulosa cells; n = 4 for each group; *p < 0.05, nonparametric Mann–Whitney test. C Representative images of antral follicles immunostained for H3K4me3 (red) and MSY2 (oocyte marker, green). D Quantitative analysis of H3K4me3 signals in granulosa cells and oocytes from control and PB-treated samples; n = 4 for each group; p** < 0.01, nonparametric Mann–Whitney test

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Epigenetics & Chromatin

ISSN: 1756-8935