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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation

Fig. 5

Model for AF10’s role in maintaining somatic cell identity and reprogramming. In the presence of AF10, DOT1L-mediated H3K79 methylation and expression of somatic specific genes are high. Upon silencing of AF10, H3K79me2 is reduced, and somatic specific gene expression is downregulated, resulting in higher reprogramming efficiency. This effect is dependent on AF10–DOT1L interaction but not on AF10 histone binding

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Epigenetics & Chromatin

ISSN: 1756-8935