Contribution of genetic and epigenetic changes to escape from X-chromosome inactivation

Table 1 The percentage of variably escaping (VE) genes found by DNAme that have significant differences in epigenetic marks (BH corrected p value < 0.01)

VEtype	n VE transcripts	n VE genes	H3K4me1	H3K4me3	H3K9me3	H3K27ac	H3K27me3	H3K36me3	expression
Across datasets	22	17	6%	17%	18%	17%	17%	16%	0%
Across tissues	70	40	12%	28%	7%	16%	14%	21%	39%
Between TSSs	2	1	0%	100%	0%	0%	100%	0%	0%
Within blood	74	51	2%	8%	2%	12%	4%	8%	3%
Within brain	10	9	13%	0%	0%	13%	0%	11%	0%
Within breast	29	24	0%	0%	4%	0%	0%	4%	0%
Within colon	8	4	25%	25%	0%	0%	0%	20%	0%
Within thyroid	45	27	16%	0	7%	10%	0%	24%	0%

Different categories of variable escape are included on the left. The number of variably escaping (VE) transcripts found per category and the number of unique genes are also included. Categories with 25% or more variably escaping genes found significant are bolded, excluding variable escape between TSSs for which only 1 gene was available

ISSN: 1756-8935