Fig. 2

Epigenetic marks do not change consistently with XCI status for variably escaping genes. a The number of genes with each XCI status call across all samples as assigned by Xi/Xa expression with their call by meta-status underneath. b The correlation of histone marks and Xi/Xa expression determined XCI status. On the left for each mark is a comparison to the overall XCI status across samples per gene, with each data point being a separate gene averaged across all female samples. On the right are shown the variably escaping genes that had significant differences in the histone mark between samples that were subject to or escaping from XCI. For each gene, on the left is a comparison of each epigenetic mark vs the Xi/Xa expression ratio for each informative sample, with allelic expression on the X axis and the epigenetic mark on the Y axis; on the right is the data for all samples, split by sex. A p-value of 0.05 was used for significance. Unknown XCI status is for samples that were uninformative in the Xi/Xa expression analysis. The scale for expression has been reduced, as there are many genes whose expression is much larger than BCOR, making the differences indistinguishable