Fig. 1

The Xi has more heterochromatic and less euchromatic marks than the Xa. a Normalized values for each histone mark, split by sex and XCI status. Each data point is the median normalized ChIP-seq signal across samples for one TSS, enhancer or transcript. All marks noted with (P) had data within 500 bp of the promoter used, while H3K4me1 used enhancers and H3K36me3 used gene body signal. b a diagram showing our Xi/Xa calculation. c, d Log₂(Xi/Xa ratio) for the histone marks examined here at promoters (c) and enhancers (d), split by XCI meta-status. Data from CEMT is shown. Underneath, the adjusted p-values for various t-test comparisons are shown, with colors denoting which groups are being compared. See Additional file 3: Table S2 for other comparisons. There are 102 transcripts which escape XCI and 993 transcripts which are subject to XCI. There are 1036 enhancers annotated to genes which escape from XCI and 5077 which are annotated to genes which are subject to XCI