Skip to main content
Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: Programmed suppression of oxidative phosphorylation and mitochondrial function by gestational alcohol exposure correlate with widespread increases in H3K9me2 that do not suppress transcription

Fig. 1

Comparison of transcriptomes between control, alcohol-exposed unaffected, and affected offspring. Pregnant dams were injected with 2.9 g/kg EtOH on gestational day-seven, and on gestational day-17, individual embryos were sorted based on the presence of ocular and cortical patterning defects. We dissected the fetal cortex and analyzed the transcriptome using deep-sequencing. A Volcano plots comparing offspring between the indicated groups (n = 3). B The top four biological categories identified using Ingenuity Pathway Analysis. C Validation of identified candidate genes within the Oxidative Phosphorylation, Mitochondrial Dysfunction, and EIF2 Signaling pathways. Analysis of gene expression carried out using RT-qPCR. Gene expression was normalized to transcripts encoding Gapdh and Ywhaz (n = 7). Error bars represent the SEM, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

Back to article page

Epigenetics & Chromatin

ISSN: 1756-8935