CLAMP promotes the formation of longer-range contacts more strongly on the X-chromosome than autosomes. A Log2 ratios per chromosome of interactions that are weakened after clamp RNAi (CLAMP-promoted) or strengthened (CLAMP-repressed) (source data provided in Additional file 6: Table S4). B Distribution of distances between DI anchors. On the autosomes, CLAMP-promoted interactions are shorter-range compared to autosomal CLAMP-repressed interactions. On the X-chromosome, however, CLAMP-promoted interactions are much longer-range than CLAMP-repressed (source data provided in Additional file 6: Table S4). C Distribution of distances to nearest CES or control region for CLAMP-promoted and CLAMP-repressed interactions. For all box and whisker plots, the 95% confidence interval is shown with a notch around the median line; whiskers represent 1.5 IQR, outliers have been omitted. a–b CLAMP-promoted interactions: autosomes n = 1055, X n = 103; CLAMP-repressed interactions: autosomes n = 1142, X n = 252. c Promoted n = 206, repressed n = 504; distribution of controls obtained by 100 permutations of randomly shuffling CES (see "Methods" section; source data provided as Additional file 1: Source Data file).