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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Loss of EZH2-like or SU(VAR)3–9-like proteins causes simultaneous perturbations in H3K27 and H3K9 tri-methylation and associated developmental defects in the fungus Podospora anserina

Fig. 4

Distribution of histone marks in ΔPaKmt6 and ΔPaKmt1 strains. a Visualization of H3K4me3, H3K9me3 and H3K27me3 localization across the genome in wild-type and mutant backgrounds. Domainograms (top) show significance of enrichment of H3K4me3, H3K9me3 and H3K27me3 marks in windows of varying size, according to the indicated p-value (right). ChIP-seq patterns (bottom) display histone modification coverage and MACS2 detected peaks. Both patterns are represented with the same scale on chromosomes one and five of P. anserina. Both centromeres are depicted (pink). The “Mat region” (orange) corresponds to the 800 kbp region devoid of recombination and containing the mating-type locus [93]. Repeated sequences are depicted in light blue. b Peak size distribution in the ΔPaKmt1 and ΔPaKmt6 mutant strains. Box plots showing sizes in base pairs of the MACS2-predicted peaks of H3K4me3, H3K9me3 and H3K27me3, shown in green, red and blue, respectively. The box is delimited, bottom to top, by the first quartile, the median and the third quartile. Numbers on top of each box represent the number of peaks detected. Outliers are not shown

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