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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: ΔNp63 is a pioneer factor that binds inaccessible chromatin and elicits chromatin remodeling

Fig. 3

Chromatin at ΔNp63 binding sites in K562 and NHEK. a UCSC Genome Browser image showing ΔNp63 binding sites shared in both NHEK and K562 near the TP73 gene. Chromatin State Segmentation (ChromHMM) and DNase data are plotted for both K562 and NHEK. Chromatin states are defined by the composite track of Broad ChromHMM from ENCODE (GEO GSE38163 GSM936088, GEO GSE38163 GSM936087) [66]. Fifteen HMM states are associated with different segment colors: state 1-bright red-active promoter, state 2-light red-weak promoter, state 3-purple-inactive/poised promoter, state 4-orange-strong enhancer, state 5-orange-strong enhancer, state 6-yellow-weak/poised enhancer, state 7-yellow-weak/poised enhancer, state 8-blue-insulator, state 9-dark green-transcriptional transition, state 10-dark green-transcriptional elongation, state 11-light green-weak transcribed, state 12-Gy-polycomb repressed, state 13-light gray-heterochromatin; low signal, state 14-light gray-repetitive/copy number variation, state 15-light gray-repetitive/copy number variation. b ΔNp63 sites bound in K562 and NHEK are grouped into K562 & NHEK (1037 sites), NHEK only (8195 sites), and K562 only (943 sites). Chromatin datasets are from K562 and NHEK from the ENCODE project. Average chromatin architecture in the specified cell line for ΔNp63 bound site in c both K562 and NHEK, d NHEK only, or e K562 only

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