Fig. 1
From: ΔNp63 is a pioneer factor that binds inaccessible chromatin and elicits chromatin remodeling
ΔNp63 binds inaccessible unmodified chromatin in K562. a 1980 high-confidence ΔNp63 bound sites in K562 were Kmeans clustered into 4 groups by DNase, H2AFZ, 5 active (H3K4me1, H3K4me2, H3K4me3, H3K9ac, H3K27ac), 2 repressive (H3K9me3, H3K27me3) and other (H3K79me2, H3K9me1, H3K36me3). Chromatin datasets are from K562 in the absence of ΔNp63 from the ENCODE project. b Average chromatin architecture in K562 at 1980 ΔNp63 ChIP-seq summits compared to 72,291 transcriptional start sites (TSS). Data are plotted for 2 kb flanking the summit or TSS. c Chromatin accessibility for the 1980 ΔNp63-bound sites in K562. Accessibility is defined from the synthesis track of DNase and FAIRE from ENCODE (GSM1002657) [66]. d Genomic annotation for the ΔNp63-bound sites in K562