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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature

Fig. 6

Reference epigenome enrichment analyses for the hypermethylated and hypomethylated DMRs from the genotype comparisons at each phase of neural differentiation. a Summary heatmap of top q-values for the chromHMM core 15-state enrichment analyses for the brain, embryonic stem cell derivatives (ES-derivatives), embryonic stem cells (ESC), induced pluripotent stem cells (iPSC), and neurospheres (Neurosph) categories. b Summary heatmap of q-values for Roadmap epigenomics 127 reference epigenomes 5 core histone modification enrichment analyses for the Brain, ESC, and iPSC categories. All enrichments are relative to background regions. * = q < 0.05

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