Fig. 4
From: Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing
Featured genes compared across species. Male and female DNAme values are graphed by gene and dataset. KDM6A is featured as it is concordantly escaping across species (a). KDM5C is featured because it is known to escape XCI across species but is here shown to be subject to XCI in artiodactyla (cow, sheep, pig and goat) (b). RPS4X is featured because it is a well-known primate-specific escape gene (c). Male methylation is shown in blue and female in red. Annotated CpG islands are shown under the methylation data in purple. Genes are shown colored by their XCI status with arrows at the TSS pointing in the direction of transcription. All of the methylation data shown are from WGBS. Pig did not have KDM6A annotated, but predictions from other species show it located at this CpG island. Goat did not have a CpG island or hypomethylated region at the annotated KDM6A