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Table 1 DNA methylation in ocular disease

From: Epigenetic regulation of retinal development

Disease

Gene

DNA modification

References

Age-related macular degeneration (AMD)

SKI, GTF2H4, TNXB

GSTM1/5

IL17RC

Hypermethylation

Hypomethylation

[161,162,163,164]

Cataract

Klotho, Cryaa, GSTP1, TXNRD2

Hypermethylation

[165,166,167,168]

Glaucoma

*Open-angle glaucoma

Alu, Hsp70

*HERV-K

Hypomethylation

Hypermethylation

[169, 170]

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Epigenetics & Chromatin

ISSN: 1756-8935