Fig. 6
From: Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent multiple sclerosis risk
An example of differential methylation at myeloid VDR peaks overlapping with MS risk genes. In cells of paediatric origin, DNA methylation was increased at IRF8 (left) and decreased at TNIP3 (right) relative to cells of adult origin. Both genes were also differentially expressed between cells of adult and paediatric origin (see Additional file 7). Black arrows denote differentially methylated regions. Red tracks: paediatric, blue tracks: adult