Fig. 5
From: Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent multiple sclerosis risk
Differentially expressed genes, associated gene ontologies and DNA methylation overlap. a Number of genes demonstrating changes in expression (> twofold) due to calcitriol in cells of adult and paediatric origin. b A minority of common genes are differentially expressed in response to calcitriol amongst cells of adult and paediatric origin. c Overlap between differentially expressed genes and differentially methylated myeloid VDR peaks/genes when comparing cells of adult and paediatric origin. d Scatter plot of overlapping sites from c corresponding to annotated promoter regions. There was a significant negative correlation between methylation difference (paediatric–adult) and log fold-change (paediatric/adult). e Overrepresented GO biological process terms (FDR < 0.05)