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Table 1 Fold enrichment of mutant H3 internal nucleosome sites

From: Global histone protein surface accessibility in yeast indicates a uniformly loosely packed genome with canonical nucleosomes

Sample

MNase

AP/input

Fold enrichment

WT H3

Low

0.068

1.0

H3 S102C

Low

0.044

0.65

H3 A110C

Low

0.042

0.62

WT H3

Medium

0.018

1.0

H3 S102C

Medium

0.017

0.94

WT H3

High

0.093

1.0

H3 S102C

High

0.045

0.49

H3 A110C

High

0.054

0.58

  1. Fold enrichment is calculated by dividing the ratio of AP/input of the mutant by that of the wild type. The AP/input ratios are determined by calculating the ratio of yeast:mouse aligned reads for each sample. Fold-enrichment values of ~ 1 or less indicate no enrichment for the internal H3 mutants
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Epigenetics & Chromatin

ISSN: 1756-8935