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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling

Fig. 4

Functional annotation of significant DMRs reveals differential methylation at alternative MAP2K3 exons leading to coordinated MKK3 expression. a KEGG pathway analysis of CNF and PNF methylation profiles confirms that multiple pathways are regulated epigenetically including growth factor, inflammatory, pain signaling and oxytocin pathways. b, c Differential methylation was observed in upstream regulatory sites in MAP2K3 that control alternative leading exon expression. d Western blot analysis of MKK3 protein (actin loading control). Beta-values for tumor-type DMRs (DMR1/DMR2) shown below. e DMR1 beta-values correlate strongly with MKK3/Actin ratio expression values (p < 0.01; = − 0.846)

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