Fig. 4From: Post-translational modifications of PRC2: signals directing its activityPRC2 subunits are modified by PTMs. The domain architecture of the PRC2 subunits and the schematic mapping of various PTM sites in the protein sequence are shown. PTM sites in EZH2, SUZ12, EED and JARID2 were taken from the indicated publications or public databases in PhosphoSitePlus® (https://www.phosphosite.org) with a minimum of 5 references, while the PTM sites in ESC (Drosophila) were predicted from public databases in SCANSITE 4.0 (https://scansite.mit.edu) with the sites matching the predicted motif sites of Casein Kinase 2 (CK2). SBD, SANT1-like binding domain; EBD, EED-binding domain; BAM, β-addition motif; SAL, SET activation loop; SANT1L/2L, SANT1/2-like; MCSS, motif connecting SANT1L and SANT2L; CXC, cysteine-rich domain; SET, catalytic domain of EZH2; ZnB, zinc finger-binding; WDB1/2, WD-40 binding domain1/2; Zn, Zn finger region; VEFS, VRN2-EMF2-FIS2-SUZ12 domain; UIM, ubiquitin-interaction motif; TR, transrepression; RBR, RNA-binding region; JmiN/C, Jumonji N/C; ARID, AT-rich interaction domainBack to article page