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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Post-translational modifications of PRC2: signals directing its activity

Fig. 3

Facultative subunits regulating PRC2 activity. (Left) Subunits in PRC2.1 regulate recruitment and activity. All PCLs can recruit PRC2.1 to unmethylated CGI and associate with H3K36me3 for specific targeting. In addition, PHF1 can extend the residence time of PRC2 in chromatin and stimulate its catalytic activity. PALI1 can stimulate the catalytic activity of PRC2.1, whereas its mutually exclusive subunit EPOP is likely to associate with EloB/C to maintain low levels of transcription. (Right) Subunits in PRC2.2 regulate recruitment and activity. Both AEBP2 and JARID2 can stimulate PRC2.2 activity and increase its binding affinity to nucleosomes. AEBP2 is a stabilizing subunit of PRC2.2 and can bind to methylated DNA in vitro, but whether this binding specificity affects PRC2 recruitment remains uncertain. JARID2 can facilitate the recruitment of PRC2.2 through interaction with H2AK119ub. In addition, JARID2 recognizes and binds to GC-rich DNA in vitro, but the function of this preference remains to be determined. Finally, JARID2 can also be methylated by PRC2, which may in turn allosterically activate the enzymatic activity of PRC2. EZHIP exists in both PRC2.1 and PRC2.2 and functions as a robust inhibitor of PRC2 activity

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