Fig. 1
From: Post-translational modifications of PRC2: signals directing its activity
Schematic illustration of the assembly of the PRC2 holoenzyme. EZH2 associates with EED and EZHIP. SUZ12 functions as a structural platform that orchestrates distinct sets of facultative subunits to form PRC2.1 and PRC2.2. Circles and arrows indicate the domains of SUZ12 interacting with core PRC2 and facultative subunits. ZnB, zinc finger-binding; WDB1/2, WD-40 binding domain1/2; Zn, Zn finger region; VEFS, VRN2-EMF2-FIS2-SUZ12 domain