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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells

Fig. 4

LIG1 depletion does not affect DNA methylation maintenance in HCT116. a Western blots confirming LIG1 or UHRF1 knockdown in HCT116 cells. b, c Infinium MethylationEPIC BeadChip analysis of HCT116 cells (beta values: 0, unmethylated; 1, methylated) 12 days after incorporation of shRNAs targeting UHRF1 (b) or LIG1 (c) relative to the control cell line (shLuc, shRNA targeting luciferase). Scatter plots with density for all cytosine probes (left) and those that had beta values > 0.8 in control cells (middle) are shown. Distribution of beta-value differences (∆β) between shLuc and target knockdown for probes that were > 0.8 in control cells (n) is shown (right)

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