Fig. 11

Proposed model of Pf H2A.Z, H3K4me1, H3K18ac and H3K27ac dynamics across transcriptional units throughout the intra-erythrocytic developmental cycle. Enrichment patterns of Pf H2A.Z (green), H3K18ac (orange), H3K27ac (purple) and H3K4me1 (pink) throughout the IDC at genes expressed in ring stages or in trophozoites/schizonts. The positions of enrichment of Pf H2A.Z and the H3 modifications are indicated on the models of genes expressed in ring (a) stages during G1 (yellow genes) or (b) in trophozoites and schizonts during asynchronous S phase and mitosis (M) (tan genes). The temporal profiles of abundance of Pf H2A.Z, H3K18ac and H3K27ac at the promoters of genes expressed in (a) ring stages or (b) trophozoites and schizonts are indicated as coloured concentric circles interpolated onto the full cell cycle. Distortions in the concentric circles indicate relative abundance of the histones (modifications) in those periods. The model was interpolated from the ChIPseq experiments conducted on parasites spanning 6-h windows indicated by solid-coloured wedges at 8–14 hpi, rings (R), 30–36 hpi trophozoites (T) and 38–44 hpi schizonts (S). The profiles in the transparent wedges were inferred but are unknown, particularly whether abundance of the H3 acetylations decreased at promoters of ring stage-expressed genes between 14 and 30 hpi