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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Epigenomic landscape of enhancer elements during Hydra head organizer formation

Fig. 6

Graphical summary showing the H3K27ac mediated activation of Hydra homologs of wnt5a, wnt11, brachyury, goosecoid and pitx. Wnt signaling causes enrichment of H3K27ac on the enhancer-like elements and it is associated with transcriptional activation. Upon inhibition of the histone demethylase JMJD3/UTX (KDM6A/B), the intergenic cis-regulatory regions cannot be demethylated and are therefore not accessible for deposition of the acetyl mark on the H3K27 residue. This leads to the downregulation of the Wnt target genes and thereby disrupts Wnt directed morphogenesis in Hydra

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