Fig. 2

Molecular dynamics simulation analysis of wild type and mutant PfYTH2 proteins in complex with RNA. a Backbone Root Mean Square Deviation (RMSD) profiles of PfYTH2 over molecular dynamics simulations time scale (picoseconds). b Spatial distance fluctuations (Angstroms), monitored over the MD simulations timescale (picoseconds) for Wild type and mutant PfYTH proteins in complex with RNA. c Distance drifts computed between PfYTH wild type and mutant proteins with m6A residue from RNA (nanometers), monitored over the MD simulations timescale (picoseconds). d The table presents the calculated PfYTH (wild type and mutants)–RNA complex potential energy values over the molecular dynamics simulation time scale