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Table 1 List of known histone N-alpha terminal modifications and their associated NTTs

From: Histone N-alpha terminal modifications: genome regulation at the tip of the tail

Histone

Species

Enzyme

Recognition motif

Biological function(s)

References

Nt-acetylation

 H1

Detected in mouse and human cells

Potentially various NATs

Various

Not known

[18, 68, 69]

 H4/H2A

Conserved from yeast to human

NAA40

SGRG

Response to caloric restriction; role in carcinogenesis

[26] [30]

 H2B

Yeast

NAA10

S

Not known

[40, 41]

Nt-methylation

 CENP-A (H3 variant)

Mammalian species

NTMT1

GPR

Formation of CCAN

[49, 50]

 H2B

Invertebrate species from ciliates to insects

NTMT1

PPK

Stress response

[51]