Table 1 List of known histone N-alpha terminal modifications and their associated NTTs
From: Histone N-alpha terminal modifications: genome regulation at the tip of the tail
| Histone | Species | Enzyme | Recognition motif | Biological function(s) | References |
|---|---|---|---|---|---|
| Nt-acetylation | |||||
| H1 | Detected in mouse and human cells | Potentially various NATs | Various | Not known | [18, 68, 69] |
| H4/H2A | Conserved from yeast to human | NAA40 | SGRG | Response to caloric restriction; role in carcinogenesis | [26] [30] |
| H2B | Yeast | NAA10 | S | Not known | [40, 41] |
| Nt-methylation | |||||
| CENP-A (H3 variant) | Mammalian species | NTMT1 | GPR | Formation of CCAN | [49, 50] |
| H2B | Invertebrate species from ciliates to insects | NTMT1 | PPK | Stress response | [51] |