Fig. 5
From: Histone N-alpha terminal modifications: genome regulation at the tip of the tail
The role of NTMT1-mediated N-me [3] CENP-A in maintaining proper kinetochore formation and function. Nt-trimethylation of the centromere specific histone CENP-A (N-me [3] CENP-A) by NTMT1 methyltransferase recruits the CENP-T and CENP-I components of the CCAN complex at centromeric chromatin to secure kinetochore function and accurate segregation of chromosomes. Lack of Nt-methylation impairs the proper localization of CENP-T and CENP-I at the centromere therefore leading to chromosome missegregation and multipolar spindle formation, which has been shown to accelerate tumour formation in p53-/- colorectal cells [49]