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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Molecular mechanism of histone variant H2A.B on stability and assembly of nucleosome and chromatin structures

Fig. 4

The L2 and the missing C-terminal tail in H2A.B are also responsible for the DNA unwrapping. a Average number of contacts of each residue in H2A with the DNA during the AA-MD simulations. The Nt, the L2 and the Ct are labeled. b Average number of contacts of each residue in H2A.B with the DNA during the AA-MD simulations. The Nt and the L2 are labeled. In a, b, for each system, average values calculated from the three independent simulations are plotted, and standard deviations are shown as errors that are represented by shade. The contact numbers from the two copies of the same histone in one nucleosome structure are also averaged. c Detailed interactions between the L2 and DNA in the H2A NCP. The base pairs in contact with the H2A L2 are colored in pink. d The interactions are significantly decreased in the H2A.B NCP. The base pairs in contact with the H2A.B L2 are colored in pink. e The H2A Ct has interactions with the DNA end in the H2A NCP, but f H2A.B has no Ct. The base pairs in contact with the Ct are colored in pink

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