Systematic genetic and proteomic screens during gametogenesis identify H2BK34 methylation as an evolutionary conserved meiotic mark

Table 3 List of new histone modifications identified in S. cerevisiae

Identified in this study and not documented elsewhere
Residue	Spo. eff.	Comment	References
H2A S10ph
H2B K30ac
H2B S41-S42 ph^a
H2B K49ac		Acylated in human (H2B K46)	[31, 91, 92]
H2B K82ac		Methylated in human (H2B K79me1)	[16]
H2B S125-T128 ph^a
H3 R40me1

Identified in this study, not described in S. cerevisiae but identified in other species
Yeast residue	Spo. eff.	Mammalian residue	References
H2A R30me1, me2		H2A R29me1, me2	[93]
H2A R89me2		H2A R88me1	[16]
H2B T39ph		H2B T36ph	[94, 95]
H2B K88ac		H2B K85ac	[16, 31, 96, 97]
H2B K111ac		H2B K108ac	[61, 91, 98, 99]
H3 S28ph		H3 S28ph	[100]
H3 S57ph		H3 S57ph	[55]
H3 R83me1, me2		H3 R83me1, me2	[61]
H4 R17me1		H4 R17me1, me2, me3	[61]
H4 K31ac		H4 K31ac	[101]
H4 K31me1		H4 K31me1	[101]

Identified in this study, not described in S. cerevisiae but other modification of the same residue identified in yeast
Residue	Spo. eff.	Known modifications	References
H2A K21ac		Succinylation	[92]
H2A K21me1		Succinylation	[92]
H2A K126ac		Sumoylation	[102]
H2B K37ac		Methylation (me1)	[67]
H2B K46ac		Formylation, succinylation, 2-hydroxyisobutyrylation	[92]
H2B K46me1		“	[92]
H2B K111ac		Methylation	[67]
H2B K123ac		Ubiquitination	[103]
H3 K42ac		Methylation	[104]

The column “Spo. eff.” represents sporulation efficiencies in the SK1 background (color-coded as described in Fig. 3f for H2A and H2B and in Ref. [33] for H3 and H4)
^aThe phosphorylation site could not be precisely mapped

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