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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: HiCoP, a simple and robust method for detecting interactions of regulatory regions

Fig. 3

HiCoP efficiently detects open chromatin interactions. a Schematic diagram of HiCoP assay. b Venn diagram of the peaks of CoP-seq and HiCoP (left) and peak annotation of HiCoP assay (right) in K562 cells. c HiCoP 3D, HiCoP 1D, CoP, HiChIP 3D, and HiChIP 1D signal enrichment at MYO3B locus in IGV. PETs are called from two replicates by using HiC-Pro. Loops are enriched in MYO3B enhancer (highlighted in gray). d Heatmaps and e subtraction heatmap of HiCoP, HiChIP (H3K27ac), and HiC on chromosome 1. The numbers below the heatmaps are resolution. The interaction matrix was displayed in juicerbox. The data were normalized by using the Knight–Ruiz balancing. Red represents positive value, blue negative value. HiC and HiChIP(H3K27ac) data are downloaded from SRA database (HiC: SRR1658693, SRR1658694; HiChIP: SRR5831492, SRR5831493)

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