Fig. 5
From: DAMEfinder: a method to detect differential allele-specific methylation
FDR control of p value assignment strategies. We plot the FDR against the TPR achieved by the two alternatives for assigning p values to a DAME: the first by generating permutations and setting a threshold K (see text) on the t-statistic (here 0.2, 0.5, 0.8), the second using the Simes method. Lines are colored by strategy. Each strategy was run 50 times with the same simulation parameters. Colored circles indicate that the FDR achieved is smaller than the specified threshold (dashed lines at 0.01, 0.05 and 0.1), and white circles indicate the opposite. x-axis is square-root transformed