Fig. 4
From: DAMEfinder: a method to detect differential allele-specific methylation
\(\text{ASM}_{\text{tuple}}\) distribution in the genome. We used XCI as a proof of concept for allele specificity in females. Data from the blood dataset comprising 3 females and 3 males were used for this analysis. a When considering all CpG tuples in the genome, the \(\text{ASM}_{\text{tuple}}\) distribution (y-axis) in chromosome 3 and chromosome X is similar in both genders. b When considering CpG tuples located in promoter regions (i.e., 1 kb upstream of the TSS), the \(\text{ASM}_{\text{tuple}}\) score is higher in chromosome X of females. c Promoter regions of 89 known imprinted regions (see “Methods”) also exhibit higher \(\text{ASM}_{\text{tuple}}\) compared to values in the rest of the genome. Y-axis in all plots is square-root transformed