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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: DAMEfinder: a method to detect differential allele-specific methylation

Fig. 3

Comparison of the \(\text{ASM}_{\text{tuple}}\) score to allelicmeth, amrfinder and methylation deviation, by considering \(\text{ASM}_{\text{snp}}\) as true ASM. We calculated \(\text{ASM}_{\text{tuple}}\) scores (red), deviations from 50% methylation (blue), allelicmeth scores (green), amrfinder scores (purple) in a sample of normal colorectal mucosa included in the CRC dataset. The scores were compared to each other by plotting the FPR against the TPR achieved. The plots are drawn for different intervals of read coverage (5–9, 10–49, \(\ge\) 50), and different levels of the \(\text{ASM}_{\text{snp}}\) score (\(\ge\) 0.5, \(\ge\) 0.8), which is considered the “true” ASM. Overall AUCs (area under the curve) for the top three panels: \(\text{ASM}_{\text{tuple}}\) = 0.83, deviations from 50% = 0.81, allelicmeth = 0.66, amrfinder = 0.68. Overall AUCs for the lower three panels: \(\text{ASM}_{\text{tuple}}\) = 0.82, deviations from 50% = 0.81, allelicmeth = 0.64, amrfinder = 0.72

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