Fig. 2

\(\text{ASM}_{\text{tuple}}\) weighting strategy. We show 4 examples of read-patterns in a single tuple. a All cases have 8 reads covering a single tuple. Example 1 has \(X_{\text{MM}}^{i}\) and \(X_{\text{UU}}^{i} = 4\), and \(X_{\text{UM}}^{i}\), \(X_{\text{MU}}^{i} = 0\). Example 2 \(X_{\text{MM}}^{i} = 8\), the rest of combinations 0. Example 3 \(X_{\text{UM}}^{i}\), \(X_{\text{MU}}^{i} = 4\), and example 4 \(X_{\text{UU}}^{i}\), \(X_{\text{UM}}^{i} = 4\). b Probability density function (PDF) for each \(\text{Beta}(\gamma +X_{\text{MM}}^{i}, \gamma +X_{\text{UU}}^{i})\) of the 4 examples, when \(\gamma = 0.5\). Pink-shaded area corresponds to \(0.5 \pm \epsilon\), when \(\epsilon = 0.2\). c Based on the PDF, we calculate the log-odds ratio (top), and the log-odds ratio multiplied by \(w_i\) (bottom)