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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Linker histone epitopes are hidden by in situ higher-order chromatin structure

Fig. 6

Average H1 epitope exposure in undifferentiated HL-60/S4 cells around transcription start sites, “open” chromatin regions and CpG islands. a, b xChIP and xxChIP signals around TSS for two groups of genes, sorted by their normalized expression in HL-60/S4 cells (Teif et al.[ 31]): 3000 genes with expression at the top percentile (a) and 3000 genes with expression at the bottom percentile (b). c xChIP and xxChIP H1 profiles around “open” chromatin regions (ENCODE DNase I hypersensitive regions in HL-60 cells) [34]. d xChIP and xxChIP H1 profiles around CpG islands. Both xChIP and xxChIP datasets reveal an average “dip” in H1 epitope exposure around the middle of TSS regions; but, clearest with the top percentile genes. The “dip” observed with xChIP may represent the occupancy paucity of H1 in the TSS; xxChIP may emphasize an additional steric “hiding” of the H1 epitopes by proteins involved in active gene expression

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