| Tool | |||||
---|---|---|---|---|---|---|
 | BAMscale | IGVtools | bedtools | MACS (callpeak followed by bedgraph2bigwig (UCSC)** | MACS (pileup followed by bedgraph2bigwig (UCSC)** | deeptools |
Creating coverage tracks | ||||||
 ChIP-seq/ATAC-seq | X | X |  | X | * | X |
 ChIP-seq/ATAC-seq (normalized) | X |  |  | X |  | X |
 Log2 coverage (replication timing) | X |  |  |  |  | X |
 OK-seq (RFD calculation) | X |  |  |  |  |  |
 RNA-seq | X | * |  | * | * | X |
 RNA-seq (splice-aware) | X |  |  |  |  |  |
 Stranded coverage | X |  |  |  |  | X |
Quantifying peaks | ||||||
 Raw read counts | x |  | x |  |  |  |
 Normalized read counts | x |  |  |  |  |  |