Fig. 2

Output comparison of approaches for computing differential accessibility. a Output comparison of 8 approaches described in Fig. 1 for calling significant DA regions in ATAC-seq data, separated by increasing vs. decreasing accessibility regions. b Comparison of same 8 approaches divided by significant DA promoter regions (within 3 kb of a TSS) vs. distal (further than 3 kb of a TSS). c Comparison of significant DA promoter regions in all 8 approaches segregated by increasing vs. decreasing accessibility. d Quantification of overlapping genes associated with a significant DA promoter region between all 8 approaches. e Gene set enrichment of Hallmark MSigDB pathways among genes with DA promoters for all 8 approaches. Enrichment displayed as observed/expected ratio, where red values indicate pathway overrepresentation