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Fig. 8 | Epigenetics & Chromatin

Fig. 8

From: EPIGENE: genome-wide transcription unit annotation using a multivariate probabilistic model of histone modifications

Fig. 8

a Overview of potential primary miRNAs predicted by EPIGENE in HepG2. b Example of an EPIGENE-predicted TU overlapping a microRNA cluster in HepG2 cell line. This region is located between lincRNA RP11-738B7.1 and gene NRF1. The TU shows an enrichment of H3K27ac and H3K4me3 at TSS (tracks shown in light violet), H3K36me3 in gene body (tracks shown in green), enhancer mark H3K4me1 few bps upstream and downstream of TSS (tracks shown in pink), GRO-seq in TSS (tracks shown in brown) and RNA Polymerase II ChIP-seq in TSS (tracks shown in blue). The predictions also show an absence of repression marks H3K27me3 and H3K9me3 (tracks shown in black) and RNA-seq evidence (tracks shown in dark pink)

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