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Fig. 7 | Epigenetics & Chromatin

Fig. 7

From: EPIGENE: genome-wide transcription unit annotation using a multivariate probabilistic model of histone modifications

Fig. 7

Example of EPIGENE-predicted TU that lacks RNA-seq evidence. The TU was predicted to be active in K562 but not in HepG2 and IMR90, and is located between pseudogene CASP3P1 and lncRNA RP5-952N6.1. The TU (shown in dark blue in EPIGENE-K562 track) shows an enrichment of H3K27ac and H3K4me3 at TSS (tracks shown in light violet), H3K36me3 in gene body (tracks shown in green), enhancer mark H3K4me1 few bps upstream of TSS (tracks shown in pink), GRO-seq in TSS (tracks shown in brown), K562 RNA Polymerase II in TSS and gene body (tracks shown in blue). The TU also shows an absence of repression marks H3K27me3 and H3K9me3 in K562 (tracks shown in black). We additionally observe the enrichment of repression mark in H3K27me3 in HepG2 and IMR90 indicating that the region is repressed in both these cell lines. There is a negligible RNA-seq evidence (shown in dark pink in K562-RNA-seq track) for this predicted TU

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