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Table 2 Human DNMT1-dependent genes altered by rotenone

From: The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure

GeneLog2FCFDRRegion typeFunction/process
MYH3− 1.623.31E−09IntragenicMyosin protein; cell movement and transport
PPFIA4− 1.372.59E−13IntragenicNeurotransmitter release synaptic function
COL9A2− 0.791.53E−04IntragenicCollagen; extracellular matrix organization
DNAAF3− 0.783.59E−02IntragenicDynein protein assembly; cell movement
LRRC8D− 0.788.42E−05IntragenicIon channel protein; neurotransmission
PLEKHG4− 0.652.74E−03IntragenicGuanine exchange factor; cell signaling
ADRA2C0.592.93E−02IntergenicNeurotransmitter release synaptic function
EML20.625.99E−05PromoterMicrotubule protein; synaptic function
HCN20.661.10E−03IntragenicVoltage gated ion channel; action potential
KDM7A0.671.16E−04IntergenicHistone demethylase; neurodevelopment
PHLDB30.763.75E−04IntragenicEnzyme binding; cell growth and proliferation
GIPR0.762.37E−02PromoterGastric inhibitory peptide; insulin release
BCL30.782.00E−02IntragenicProto-oncogene; cell growth and proliferation
NEFM0.804.33E−07IntragenicNeurofilament; synaptic function
  1. Log2FC is the log base twofold change of the fragments per kilobase of exon per million fragments mapped (FPKM) or “read counts” of the rotenone-treated HEK293 relative to the vehicle control. FDR is the adjusted p value using the false-discovery rate correction for multiple hypotheses