Fig. 5
Altered CpG methylation at HCN2 human DNMT1-dependent locus. a Genomic location of identified HCN2 DNMT1-dependent region. The DNA element and distance from the transcription start site are annotated in black. The primer region box indicates the amplified region for Bisulfite-sequencing. b The percent methylation of all CpG sites within the amplified region. Delta indicates the change in the mean CpG methylation percentage and the associated false-discovery rate. c The percent methylation of individual CpG sites within the amplified region. Significant differentially methylated cytosines are indicated by * (Δ > 1%; q value < 0.01)