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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure

Fig. 4

Regional expression of DNMT1-dependent genes altered by rotenone. Human DNMT1-dependent genes that were differentially expressed (≥ 1.5-fold change, false-discovery rate FDR ≤ 0.05) in response to rotenone were used for regional expression analysis in the Genotype-Tissue Expression (GTex) database [46]. Brain regions selected are associated with Parkinson’s disease pathogenesis and important for motor function control. The heat map was generated using GTex and organization is clustered by gene function and tissue function. The color of each square indicates the level of expression of the gene in the selected region in transcripts per kilobase million (TPM) represented by the color bar (dark blue = higher expression)

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